Phenotypes for Tbx5 Tg(Prrx1-cre)1Cjt MGI:3623770 MGI Mouse

abnormal abdominal wall morphology ( J:217810 )

• due to absence of the sternum, the ribcage fails to close and associated herniation of internal organs and failure of abdominal body wall closure is seen

perinatal lethality ( J:83258 )

absent apical ectodermal ridge ( J:83258 )

abnormal forelimb bud morphology ( J:83258 )

• no limb outgrowth and morphologically distinguishable apical ectodermal ridge are visible in the forelimb region; limb defect is manifest by E10.5

• cells of the prospective forelimb undergo extensive apoptosis by E9.5

absent forelimb buds ( J:83258 )

• at E10.5

absent forelimb ( J:83258 , J:217810 )

• forelimbs of newborns are completely absent, however the hindlimbs are unaffected (J:83258)

• some newborns have a small, rudimentary flap of skin on one side of the embryo where the forelimb would normally form (J:83258)

absent clavicle ( J:83258 )

absent scapula ( J:83258 )

abnormal thoracic cage morphology ( J:83258 , J:217810 )

• ribcage fails to fuse (J:83258)

• due to absence of the sternum, the ribcage fails to close (J:217810)

absent sternum ( J:83258 , J:217810 )

• mice completely lack a sternum (J:217810)

• sternal bands do not form in E12.5-E13.5 embryos (J:217810)