Phenotypes Associated with This Genotype

Genotype
MGI:3623607

• Allelic Composition: Npr3^tm1Unc/Npr3⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:56058 )

• heterozygotes display progressively increased red blood cell counts relative to wild-type mice (10.1 0.3 10⁶/mm³ vs 9.7 0.1 10⁶/mm³, respectively)

increased hematocrit ( J:56058 )

• heterozygotes display progressively increased hematocrits relative to wild-type mice (51.8 0.9 vs 49.9 1.0, respectively)

increased hemoglobin content ( J:56058 )

• heterozygotes display progressively increased hemoglobin levels relative to wild-type mice (16.2 0.2 g/dl vs 15.6 0.2 g/dl, respectively)

homeostasis/metabolism

abnormal urine nucleotide level ( J:56058 )

• homozygotes exhibit a >200% increase in total daily excretion of cGMP in the urine relative to wild-type mice

decreased urine osmolality ( J:56058 )

• heterozygotes can excrete dilute urine after water loading but become progressively and significantly less able to concentrate urine relative to wild-type mice

cardiovascular system

hypovolemia ( J:56058 )

• heterozygotes exhibit reduced intravascular blood volume; however, no reduction in blood pressure is observed relative to wild-type mice

renal/urinary system

abnormal urine nucleotide level ( J:56058 )

• homozygotes exhibit a >200% increase in total daily excretion of cGMP in the urine relative to wild-type mice

decreased urine osmolality ( J:56058 )

• heterozygotes can excrete dilute urine after water loading but become progressively and significantly less able to concentrate urine relative to wild-type mice

polyuria ( J:56058 )

• similar to homozygotes, heterozygotes show a mild progressive increase in total daily urine output relative to wild-type littermates