Analysis Tools
reproductive system
immune system
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• impaired engulfment of apoptotic thymocytes
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• age dependent splenomegaly
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hematopoietic system
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• impaired engulfment of apoptotic thymocytes
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• age dependent splenomegaly
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endocrine/exocrine glands
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• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
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• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
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integument
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• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
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|
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• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
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growth/size/body
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• age dependent splenomegaly
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cellular
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• impaired engulfment of apoptotic thymocytes
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