Phenotypes Associated with This Genotype

Genotype
MGI:3623578

• Allelic Composition: Casp3^tm1Mak/Casp3^tm1Mak; Tg(TcrLCMV)327Sdz/0
• Genetic Background: B6.Cg-Casp3^tm1Mak Tg(TcrLCMV)327Sdz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:97650 )

• after injection with streptozocin for 5 consecutive days, blood glucose in caspase-3-homozygous transgenic mice remains normoglycemic for the duration of the study

cellular

decreased cell proliferation ( J:97650 )

• adoptive transfer of labeled Tg(TcrLCMV)327Sdz-transgene positive T cells, examination of pancreatic draining lymph nodes showed that only 45% of the transferred T cells had undergone proliferation compared to 62% in caspase-3-heterozygous transgenic recipients

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:97650 )

• in CD8+ T cells isolated from pancreatic draining or non-draining lymph nodes of streptozocin-treated mice, 32% of the CD8+ cells are CD69hi positive and 9% respectively, compared to corresponding values of 3% and 5% respectively in caspase-3-heterozygous transgenic mice

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:97650 )

• in CD8+ T cells isolated from pancreatic draining or non-draining lymph nodes of streptozocin-treated mice, 32% of the CD8+ cells are CD69hi positive and 9% respectively, compared to corresponding values of 3% and 5% respectively in caspase-3-heterozygous transgenic mice