Mouse Genome Informatics
hm
    Casp3tm1Mak/Casp3tm1Mak
B6.129P2-Casp3tm1Mak
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about 50% of homozygotes survive to adulthood

homeostasis/metabolism
• after injection with streptozocin for 5 consecutive days, blood glucose in homozygotes remains normoglycemic for the duration of the study and pancreas samples showed normal islets

immune system
• islets from homozygous mice show no infiltration at any time after streptozocin treatment compared to heterozygotes (J:97650)
• after treatment with TNF unlike in wild-type mice swollen villi, an increase in infiltrates, and high levels of apoptosis are almost absent (J:179279)
• however, cytokine concentrations, hypothermia, and mortality after TNF treatment are similar to wild-type controls (J:179279)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:97650