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Phenotypes Associated with This Genotype
Genotype
MGI:3623576
Allelic
Composition
Casp3tm1Mak/Casp3tm1Mak
Genetic
Background
B6.129P2-Casp3tm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp3tm1Mak mutation (1 available); any Casp3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 50% of homozygotes survive to adulthood

homeostasis/metabolism
• after injection with streptozocin for 5 consecutive days, blood glucose in homozygotes remains normoglycemic for the duration of the study and pancreas samples showed normal islets

immune system
• islets from homozygous mice show no infiltration at any time after streptozocin treatment compared to heterozygotes (J:97650)
• after treatment with TNF unlike in wild-type mice swollen villi, an increase in infiltrates, and high levels of apoptosis are almost absent (J:179279)
• however, cytokine concentrations, hypothermia, and mortality after TNF treatment are similar to wild-type controls (J:179279)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:97650


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory