Mouse Genome Informatics
ht
    Prf1tm1Sdz/Prf1+
NOD.B6-Prf1tm1Sdz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• at 8 weeks of age, insulitis is seen to varying degrees in perforin-null and heterozygous mice; by 55 weeks of age, in non-diabetic null mice, severe insulitis develops with a higher frequency than in perforin- expressing NOD controls
• periinsulitis is observed in 8-week old perforin-null and heterozygous mice with little islet cell damage, compared to detection at 5 weeks in control NOD mice
• female heterozygous NOD mice show a delayed incidence (median: week 27) in development of diabetes (determined by high blood glucose) with an incidence of 67% compared to early onset (median: week 19) with an incidence of 77% in control NOD mice

endocrine/exocrine glands
• at 8 weeks of age, insulitis is seen to varying degrees in perforin-null and heterozygous mice; by 55 weeks of age, in non-diabetic null mice, severe insulitis develops with a higher frequency than in perforin- expressing NOD controls
• periinsulitis is observed in 8-week old perforin-null and heterozygous mice with little islet cell damage, compared to detection at 5 weeks in control NOD mice