Phenotypes Associated with This Genotype

Genotype
MGI:3623519

• Allelic Composition: Prf1^tm1Sdz/Prf1⁺
• Genetic Background: NOD.B6-Prf1^tm1Sdz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:43468 )

• at 8 weeks of age, insulitis is seen to varying degrees in perforin-null and heterozygous mice; by 55 weeks of age, in non-diabetic null mice, severe insulitis develops with a higher frequency than in perforin- expressing NOD controls

periinsulitis ( J:43468 )

• periinsulitis is observed in 8-week old perforin-null and heterozygous mice with little islet cell damage, compared to detection at 5 weeks in control NOD mice

decreased susceptibility to autoimmune diabetes ( J:43468 )

• female heterozygous NOD mice show a delayed incidence (median: week 27) in development of diabetes (determined by high blood glucose) with an incidence of 67% compared to early onset (median: week 19) with an incidence of 77% in control NOD mice

endocrine/exocrine glands

insulitis ( J:43468 )

• at 8 weeks of age, insulitis is seen to varying degrees in perforin-null and heterozygous mice; by 55 weeks of age, in non-diabetic null mice, severe insulitis develops with a higher frequency than in perforin- expressing NOD controls

periinsulitis ( J:43468 )

• periinsulitis is observed in 8-week old perforin-null and heterozygous mice with little islet cell damage, compared to detection at 5 weeks in control NOD mice