Phenotypes Associated with This Genotype

Genotype
MGI:3623487

• Allelic Composition: Col1a1^tm1.1Jcm/Col1a1⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:59168 )

• some F1 pups die within 3-4 hours after birth from respiratory distress, although some survive past 1 year of age

growth/size/body

decreased body size ( J:59168 )

• those surviving the neonatal period are 50-80% the size of wild-type

respiratory system

respiratory distress ( J:59168 )

• some F1 pups die within 3-4 hours after birth from respiratory distress

skeleton

abnormal neurocranium morphology ( J:59168 )

• F1 pups exhibit a decrease in calvarial mineralization

rib fractures ( J:59168 )

• F1 pups exhibit multiple rib fractures

short vertebral body ( J:59168 )

• F1 pups have shorter vertebral bodies

decreased bone mineralization ( J:59168 )

• F1 pups exhibit a decrease in calvarial mineralization

craniofacial

abnormal neurocranium morphology ( J:59168 )

• F1 pups exhibit a decrease in calvarial mineralization