Phenotypes Associated with This Genotype

Genotype
MGI:3623466

• Allelic Composition: Tg(Myh6-SLC2A1)54Rti/0
• Genetic Background: FVB-Tg(Myh6-SLC2A1)54Rti

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:106467 )

• mice subjected to chronic pressure overload (by ascending aortic constriction) exhibit improved survival and do not develop heart failure as do wild-type

cardiovascular system

increased cardiac muscle glycogen level ( J:106467 )

• augmented glucose uptake results in a 5-fold increase in cardiac glycogen

increased cardiac muscle cell glucose uptake ( J:106467 )

• uptake rate of a glucose analog is increased about 40-fold in isolated hearts during insulin-free perfusion and remains more than 2-fold higher than wild-type during insulin stimulation, however blood glucose levels are unaltered

• greater rate of glucose uptake persists in hearts after pressure overload by ascending aortic constriction

abnormal response of heart to induced stress ( J:106467 )

• mice subjected to chronic pressure overload exhibit improved survival and do not develop heart failure as do wild-type

• lactate production is elevated in isolated perfused hearts at baseline and increases additionally at peak work induced by increasing left ventricle volume

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:106467 )

• augmented glucose uptake results in a 5-fold increase in cardiac glycogen

abnormal response of heart to induced stress ( J:106467 )

• mice subjected to chronic pressure overload exhibit improved survival and do not develop heart failure as do wild-type

• lactate production is elevated in isolated perfused hearts at baseline and increases additionally at peak work induced by increasing left ventricle volume

muscle

increased cardiac muscle glycogen level ( J:106467 )

• augmented glucose uptake results in a 5-fold increase in cardiac glycogen

increased cardiac muscle cell glucose uptake ( J:106467 )

• uptake rate of a glucose analog is increased about 40-fold in isolated hearts during insulin-free perfusion and remains more than 2-fold higher than wild-type during insulin stimulation, however blood glucose levels are unaltered

• greater rate of glucose uptake persists in hearts after pressure overload by ascending aortic constriction

cellular

increased cardiac muscle cell glucose uptake ( J:106467 )

• uptake rate of a glucose analog is increased about 40-fold in isolated hearts during insulin-free perfusion and remains more than 2-fold higher than wild-type during insulin stimulation, however blood glucose levels are unaltered

• greater rate of glucose uptake persists in hearts after pressure overload by ascending aortic constriction