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Phenotypes Associated with This Genotype
Genotype
MGI:3623394
Allelic
Composition
Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1atm1.1Ylee mutation (1 available); any Hnf1a mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mice are born at less than half the expected frequency (J:47008)
• homozygous mice are born at less than half the expected frequency (J:47008)

growth/size/body
• homozygotes are slightly smaller than wild-type or heterozygous littermates (J:47008)
• homozygotes are slightly smaller than wild-type or heterozygous littermates (J:47008)

homeostasis/metabolism
• 2 weeks after birth nulls develop hyperglycemia; null mice develop diabetes by 2 weeks of age (J:47008)
• 2 weeks after birth nulls develop hyperglycemia; null mice develop diabetes by 2 weeks of age (J:47008)
• at 5 and 12 weeks, the circulating insulin levels in null mice are 60% of levels in heterozygotes (J:47008)
• at 5 and 12 weeks, the circulating insulin levels in null mice are 60% of levels in heterozygotes (J:47008)
• levels of insulin-like growth factor I in the blood of null mice are only 20-30% that of control mice (J:47008)
• levels of insulin-like growth factor I in the blood of null mice are only 20-30% that of control mice (J:47008)
• at 5 weeks of age, GH levels in null mice are 100 times and 45 times higher than those in control female and male mice (J:47008)
• at 5 weeks of age, GH levels in null mice are 100 times and 45 times higher than those in control female and male mice (J:47008)
• 6 week old null mice have urine glucose levels 330x higher than heterozygotes (J:47008)
• 6 week old null mice have urine glucose levels 330x higher than heterozygotes (J:47008)
• cholesterol levels are higher in nulls than in heterozygotes (J:47008)
• cholesterol levels are higher in nulls than in heterozygotes (J:47008)

behavior/neurological
• null males show no mating behavior when paired with wild-type or null females (J:47008)
• null males show no mating behavior when paired with wild-type or null females (J:47008)

endocrine/exocrine glands
• the amount of insulin peptide and insulin-secreting cells in null mice are severely reduced (J:47008)
• the amount of insulin peptide and insulin-secreting cells in null mice are severely reduced (J:47008)
• the insulin-secreting cells in null mice are severely reduced (J:47008)
• the insulin-secreting cells in null mice are severely reduced (J:47008)

reproductive system
• reproductive organs in both sexes are underdeveloped in null animals (J:47008)
• reproductive organs in both sexes are underdeveloped in null animals (J:47008)
• null males have significantly reduced spermatogenesis (J:47008)
• null males have significantly reduced spermatogenesis (J:47008)
• null mice of both sexes are infertile (J:47008)
• null mice of both sexes are infertile (J:47008)

renal/urinary system
• 6 week old null mice have urine glucose levels 330x higher than heterozygotes (J:47008)
• 6 week old null mice have urine glucose levels 330x higher than heterozygotes (J:47008)
• null mice urinate more frequently than normal mice and diuresis is twice the control level (J:47008)
• null mice urinate more frequently than normal mice and diuresis is twice the control level (J:47008)

liver/biliary system
• hepatocytes from null mice are highly vacuolated and seemed to have an abnormal accumulation of complex carbohydrates (J:47008)
• hepatocytes from null mice are highly vacuolated and seemed to have an abnormal accumulation of complex carbohydrates (J:47008)
• livers of 5 week old null mice are 50% larger than that of normal littermates; nulls develop central lobular hyperplasia, with degeneration of individual hepatocytes obvious at 12 weeks (J:47008)
• livers of 5 week old null mice are 50% larger than that of normal littermates; nulls develop central lobular hyperplasia, with degeneration of individual hepatocytes obvious at 12 weeks (J:47008)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory