Phenotypes Associated with This Genotype

Genotype
MGI:3623308

• Allelic Composition: Egfr^Wa5/Egfr^Wa5
• Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological placentae analysis of the Egfr^Wa5/Egfr^Wa5 and Egfr^Wa5/⁺ mice

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:92308 )

• embryos surviving past E12.5 die by birth or very shortly after

embryonic lethality during organogenesis, incomplete penetrance ( J:92308 )

• morphologically normal at E10.5

• 71% lethality between E10.5 and E12.5

embryo

abnormal placenta morphology ( J:92308 )

• defective placentas with phenotypes ranging from mild defects to severely affected

decreased spongiotrophoblast size ( J:92308 )

• reduced spongiotrophoblast at E12.5

• spongiotrophoblast reduction very significant in runted embryos

abnormal placenta labyrinth morphology ( J:92308 )

• variably compromised labyrinthine layer

• multinucleated labyrinthine trophoblasts

• reduced thickness

• multiple blood pockets found in runted embryos