Analysis Tools
growth/size/body
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• at 4 weeks, mice are slightly growth retarded (14.5g) compared to wild-type (20.8g); by 8 weeks of age, there is no significant difference
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homeostasis/metabolism
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• in response to 10 and 20 mM glucose, mutant mice show much lower insulin secretion than wild-type mice
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hyperglycemia
(
J:43657
)
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• fasting blood glucose levels are higher in mutants
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• levels are comparatively low with respect to the elevated glucose levels
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• serum levels of TSH are 2-fold higher in mutants compared to wild-type and heterozygotes
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endocrine/exocrine glands
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• there is a decrease in the number of TSH-positive cells
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• in response to 10 and 20 mM glucose, mutant mice show much lower insulin secretion than wild-type mice
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nervous system
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• there is a decrease in the number of TSH-positive cells
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