Phenotypes Associated with This Genotype

Genotype
MGI:3623225

• Allelic Composition: Trh^tm1Mmt/Trh^tm1Mmt
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pituitary gland development ( J:59141 )

• in 8 week old mutants, hypoplasia is observed in thrytrophs but not in other pituitary hormone-producing cells

homeostasis/metabolism

decreased circulating thyroxine level ( J:59141 )

• in mutants by postnatal day 10, the level of thyroid hormone increases only by 3-fold from level at birth compared to a 6-fold increase in wild-type animals; levels at 21 days and 8 weeks are 28.3% and 50.3% of wild-type levels, respectively

decreased circulating thyroid-stimulating hormone level ( J:59141 )

• there is significantly decreased levels of TSH in the pituitary of homozygous mice

nervous system

abnormal pituitary gland development ( J:59141 )

• in 8 week old mutants, hypoplasia is observed in thrytrophs but not in other pituitary hormone-producing cells