Phenotypes Associated with This Genotype

Genotype
MGI:3623151

• Allelic Composition: Slc9a1^swe/Slc9a1^swe
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:43429 )

• Background Sensitivity: most of the affected F1 and F2 hybrids survive 6 months

behavior/neurological

behavioral arrest ( J:43429 )

• associated with absence seizures

seizures ( J:43429 )

• Background Sensitivity: spike-wave seizure activity is markedly enhanced compared to homozygotes on congenic backgrounds; seizures are longer in duration and very frequent by 4 weeks of age and persist several months

tonic-clonic seizures ( J:43429 )

• mutants undergo rare spontaneous generalized tonic-clonic seizure episodes as early as 14 days og age; seizures are usually of less than one minute and are preceded by several seconds of wild running

absence seizures ( J:43429 )

• electrocorticographic recording from 4-5 week old (SJL x B6) F2 mutants display frequent episodes of generalized bilaterally symmetric spike-wave activity with a rhythmic periodicity ranging from 3 to 4.5 seconds; spikes are always preceded by waves; spike wave bursts are specifically associated with complete behavioral arrest for the durationof the discharge

nervous system

seizures ( J:43429 )

• Background Sensitivity: spike-wave seizure activity is markedly enhanced compared to homozygotes on congenic backgrounds; seizures are longer in duration and very frequent by 4 weeks of age and persist several months

tonic-clonic seizures ( J:43429 )

• mutants undergo rare spontaneous generalized tonic-clonic seizure episodes as early as 14 days og age; seizures are usually of less than one minute and are preceded by several seconds of wild running

absence seizures ( J:43429 )

• electrocorticographic recording from 4-5 week old (SJL x B6) F2 mutants display frequent episodes of generalized bilaterally symmetric spike-wave activity with a rhythmic periodicity ranging from 3 to 4.5 seconds; spikes are always preceded by waves; spike wave bursts are specifically associated with complete behavioral arrest for the durationof the discharge