Phenotypes Associated with This Genotype

Genotype
MGI:3623140

• Allelic Composition: Drd2^tm1Schm/Drd2^tm1Schm; Drd3^tm1Schm/Drd3^tm1Schm
• Genetic Background: B6.Cg-Drd2^tm1Schm Drd3^tm1Schm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:106280 )

• double mutants can not keep pace with wild-type littermates in growth; nulls weigh significantly less than wild-type controls

behavior/neurological

increased fluid intake ( J:106280 )

• double nulls drink more water than wild-type

increased food intake ( J:106280 )

• double nulls eat significantly more than wild-type

digestive/alimentary system

increased defecation amount ( J:106280 )

• stool frequency in double mutants is significantly greater than in wild-type

abnormal intestinal absorption ( J:106280 )

• fast rate of GI transit prevents complete digestion or absorption of food

abnormal intestinal transit time ( J:106280 )

• mean transit time through the bowel is significantly faster in double homozygotes compared to wild-type but does not differ significantly from D2 nulls

abnormal large intestinal transit time ( J:106280 )

• transit time required to expel a glass bead inserted into the rectum a distance ot 2 cm is significantly less in double homozygotes compared to wild-type but does not differ significantly from D2 nulls