Phenotypes Associated with This Genotype

Genotype
MGI:3623123

• Allelic Composition: Drd2^tm1Schm/Drd2^tm1Schm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79483 )

• mortality between P30 and 45 is 20%

growth/size/body

decreased body size ( J:79483 )

• between P15 and 45 are smaller than wild-type littermates

decreased body weight ( J:79483 )

• between P15 and 45, homozygotes have body weights 20% less than wild-type

behavior/neurological

hunched posture ( J:79483 )

abnormal locomotor behavior ( J:79483 )

• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

bradykinesia ( J:79483 )

• adult homozygotes display bradykinesia; this only becomes apparent after P15 and is most severe between P15 and 45

homeostasis/metabolism

abnormal dopamine level ( J:79483 )

• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants