Phenotypes Associated with This Genotype

Genotype
MGI:3623107

• Allelic Composition: Ret^tm1Jmi/Ret^tm1Jmi
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:71881 )

• homozygotes die shortly after birth

cellular

increased neuron apoptosis ( J:71881 )

• at E16.5. there is more cell death observed in nulls in the SCG and stellate ganglion than in wild-type

increased cell proliferation ( J:71881 )

• by E16.5, more proliferating sympathetic neuron precursors are observed in the SCG and STG than in heterozygotes or wild-type

nervous system

increased neuron apoptosis ( J:71881 )

• at E16.5. there is more cell death observed in nulls in the SCG and stellate ganglion than in wild-type

absent enteric neurons ( J:71881 )

• homozygotes lack enteric neurons

abnormal sympathetic ganglion morphology ( J:71881 )

• the cervical sympathetic ganglion-like ganglion in nulls are found in a position caudal to the normal SCG location; the position is variable among nulls

• in null embryos, SCG primordia are round-shaped and shorter than in wild-type; at E11.5 there is about a 30% decrease in sympathetic cell number

• in the caudal region of the embryo, sympathetic precursors form clumps and do not distribute properly

small superior cervical ganglion ( J:71881 )

• the SCG in nulls display severe but variable reductions in size

abnormal prevertebral ganglion morphology ( J:71881 )

• in the prevertebral division, sympathetic ganglia are aberrantly located, reduced in size and display decreased target innervation

abnormal sympathetic neuron morphology ( J:71881 )

• in nulls, sympathetic neurons are variably reduced in size

abnormal sympathetic postganglionic fiber morphology ( J:71881 )

• there are severe deficits in axonal projections from the SCG; the internal carotid nerve displays aberrant branching and is attenuated on the course of its projection, such that sympathetic fibers in the rostral facial structures are almost entirely depleted

• sympathetic neuron precursors fail to extend long processes; this is apparent in E12.5 embryos in the SCG, STG and prevertebral ganglia

• at E15.5, nerve bundles that form the internal carotid nerve are thin and in some embryos project caudally, not rostrally

• the stellate ganglion displays severe innervation deficits such as attenuation of the vertebral nerve

abnormal innervation ( J:106244 )

• the density of esophageal neurons in null mice is only 4% of wild-type neuronal density

digestive/alimentary system

abnormal submandibular gland morphology ( J:71881 )

• there is a reduction in density and distribution of symapathetic fibers in the submandibular gland, resulting in absence of sympathetic innervation in the peripheral lobes

endocrine/exocrine glands

abnormal submandibular gland morphology ( J:71881 )

• there is a reduction in density and distribution of symapathetic fibers in the submandibular gland, resulting in absence of sympathetic innervation in the peripheral lobes

renal/urinary system

absent kidney ( J:71881 )

• homozygotes lack kidneys