Phenotypes Associated with This Genotype

Genotype
MGI:3623099

• Allelic Composition: Oprm1^tm1Uhl/Oprm1⁺
• Genetic Background: either: B6.129S7-Oprm1^tm1Uhl or (involves: 129S7/SvEvBrd)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

behavior/neurological

enhanced conditioned place preference behavior ( J:106256 )

• heterozygous mice on the mixed background show almost double the preference for compartments paired with 5 or 10 mg/kg morphine compared to wild-type

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

decreased physiological sensitivity to xenobiotic ( J:106256 )

• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type