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Phenotypes Associated with This Genotype
Genotype
MGI:3623029
Allelic
Composition		 Adcy1brl/Adcy1brl
Genetic
Background		 B6.Cg-Adcy1brl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1brl mutation (0 available); any Adcy1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired synaptic plasticity ( J:106269 )
• in mutants, paired stimuli produces less paired-pulse depression than in wild-type; paired-pulse ratios are increased in mutants compared to wild-type
abnormal excitatory postsynaptic currents ( J:106269 )
• in thalamocortical synapses, attenuation of NMDAR-mediated EPSCs by MK801 in mutants is much slower than in wild-type during repetitive stimulation with residual response detected after 40 minutes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory