Phenotypes Associated with This Genotype

Genotype
MGI:3623028

• Allelic Composition: Rims1^tm1Sud/Rims1^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

disorganized barrel cortex ( J:106269 )

• barrels corresponding to the small tactile hairs on the snout are absent or indistinct in nulls in mice aged 8-21 days; in adult mice, barrel boundaries are indistinct in mutants; a uniform distribution of layer IV neurons is observed in mutants instead of being restricted to barrels, except for a few large barrels

impaired synaptic plasticity ( J:106269 )

• in mutants, paired stimuli produces less paired-pulse depression than in wild-type; paired-pulse ratios are increased in mutants compared to wild-type

abnormal excitatory postsynaptic currents ( J:106269 )

• in hippocampal neurons, attenuation of NMDAR-mediated EPSCs by MK801 in mutants is much slower than in wild-type during repetitive stimulation

abnormal inhibitory postsynaptic currents ( J:143053 )

• reduction in eIPSC is less severe than in Rims1^tm3.1Sud homozygotes

• miniature inhibitory postsynaptic current (mIPSC) frequency is decreased compared to in wild-type mice

• reduction in mIPSC is less severe than in Rims1^tm3.1Sud homozygotes

• evoked inhibitory postsynaptic current (eIPSC) amplitude is reduced compared to in wild-type mice

abnormal paired-pulse inhibition ( J:143053 )

• mice exhibit a modest reduction in paired pulse depression compared to in wild-type mice that is less pronounced than in Rims1^tm3Sud neurons exposed to a cre-expressing lentivirus