Phenotypes Associated with This Genotype

Genotype
MGI:3623023

• Allelic Composition: Hcn2^tm1Ldw/Hcn2^tm1Ldw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:81398 )

• 15.3g bodyweight at 8 weeks of age as opposed to 26.5g in controls

behavior/neurological

tremors ( J:81398 )

• whole body tremors

decreased locomotor activity ( J:81398 )

• less horizontal locomotor activity in open field tests

• less rearing

absence seizures ( J:81398 )

• frequent bilateral synchronous spike and wave discharges indicative of absence epilepsy

nervous system

absence seizures ( J:81398 )

• frequent bilateral synchronous spike and wave discharges indicative of absence epilepsy

abnormal nervous system electrophysiology ( J:81398 )

abnormal afterhyperpolarization ( J:81398 )

• in thalamocortical neurons

abnormal summary potential ( J:81398 )

• susceptibility to oscillatory activity in thalamocortical neurons

decreased channel response intensity ( J:81398 )

• thalamocortical relay neurons with dramatically reduced inward current

• inward current reduced about 1/3 in CA1 pyramidal cells

cardiovascular system

irregular heartbeat ( J:81398 )

• variable intervals between heart beats

abnormal sinoatrial node conduction ( J:81398 )

• sinus dysrhythmia at rest but not during spontaneous activity

• variable intervals between successive heart beats

• regular P wave in a normal PR interval indicating synoatrial node dysfunction

• 30% reduced inward current of sinoatrial cells