Phenotypes Associated with This Genotype

Genotype
MGI:3622808

• Allelic Composition: Alox5^tm1Fun/Alox5^tm1Fun
• Genetic Background: B6.129S2-Alox5^tm1Fun/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total fat pad weight ( J:104825 )

• increased total fat pad weight

homeostasis/metabolism

increased circulating leptin level ( J:104825 )

increased circulating VLDL cholesterol level ( J:104825 )

• increased plasma VLDL/LDL cholesterol

skeleton

increased bone mineral density ( J:104825 )

• increased bone mineral density

immune system

decreased susceptibility to experimental autoimmune uveoretinitis ( J:108446 )

• upon adoptive transfer of IRBP1-20-specific T cells from wild-type B6 donors to wild-type and Alox5-deficient recipients, wild-type mice develop severe clinical uveitis, whereas mutant recipients show only mild and transient clinical disease