Mouse Genome Informatics
cx
    Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0

NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice
• wild-type transgenic NOD mice readily develop diabetes starting at 5 weeks (blood glucose >300 mg/dl), while ICAM-I deficient transgenic NOD mice have not developed diabetes at 12 weeks (n=4) or 16 weeks (n=5); nontransgenic ICAM-I deficient mice do not develop diabetes over the same period
• transfer of concanavalin A treated splenocytes from 8 week old Tg(TcraBDC2.5)1Doi Tg(TcraBDC2.5)1Doi female mice expressing an islet-specific TCR transgene to irradiated ICAM-I deficient NOD or deficient transgenic NOD mice does not induce diabetes in recipients

endocrine/exocrine glands
• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583