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Phenotypes Associated with This Genotype
Genotype
MGI:3622779
Allelic
Composition
Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0
Genetic
Background
NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Jcgr mutation (3 available); any Icam1 mutation (15 available)
Tg(INS-Il10)#Sar mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice
• wild-type transgenic NOD mice readily develop diabetes starting at 5 weeks (blood glucose >300 mg/dl), while ICAM-I deficient transgenic NOD mice have not developed diabetes at 12 weeks (n=4) or 16 weeks (n=5); nontransgenic ICAM-I deficient mice do not develop diabetes over the same period
• transfer of concanavalin A treated splenocytes from 8 week old Tg(TcraBDC2.5)1Doi Tg(TcraBDC2.5)1Doi female mice expressing an islet-specific TCR transgene to irradiated ICAM-I deficient NOD or deficient transgenic NOD mice does not induce diabetes in recipients

endocrine/exocrine glands
• ICAM-I deficient transgenic mice develop periinsulitis but not insulitis as do wild-type transgenic NOD mice

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory