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Phenotypes Associated with This Genotype
Genotype
MGI:3622772
Allelic
Composition		 Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:64051 )
• 100% of deficient transgenic animals develop diabetes by 5 weeks (blood glucose >300 mg/dl), while only 60% of non-transgenic littermates develop diabetes by 24 weeks

homeostasis/metabolism
increased circulating glucose level ( J:64051 )
• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory