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Phenotypes Associated with This Genotype
Genotype
MGI:3622764
Allelic
Composition
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0
Genetic
Background
involves: 129S7/SvEvBrd * BALB/c * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Clrk mutation (0 available); any Prf1 mutation (26 available)
Tg(INS-Il10)#Sar mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only 11% of animals develop diabetes by 5 weeks of age (blood glucose >300 mg/dl), while 50% of wild-type transgenic animals develop diabetes, but the overall incidence by 12 weeks is the same for both
• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:64051


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory