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Phenotypes Associated with This Genotype
Genotype
MGI:3622696
Allelic
Composition		 Lrpap1tm1Her/Lrpap1tm1Her
Tg(APPV717F)109Ili/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (23 available)
Tg(APPV717F)109Ili mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
astrocytosis ( J:107567 )
• develop reactive astrocytosis
amyloid beta deposits ( J:107567 )
• elevated amyloid deposits over controls

homeostasis/metabolism
amyloid beta deposits ( J:107567 )
• elevated amyloid deposits over controls

cellular
astrocytosis ( J:107567 )
• develop reactive astrocytosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory