Phenotypes Associated with This Genotype

Genotype
MGI:3622693

• Allelic Composition: Tg(INS-Il10)#Sar/0
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(INS-Il10)#Sar/0 mice accumulate imflammatory cells within exocrine pancreatic tissue

immune system

pancreas inflammation ( J:107927 )

• pancreas inflammation is first observed at 1 week of age with the majority of invading cells being macrophages; at 2 months, lymphocytes dominate the inflammation

periinsulitis ( J:107927 )

• in transgenic mice, the islets of Langerhans are surrounded by infiltrates of inflammatory cells: focal accumulations of mononuclear cells are observed at 4-6 weeks of age, increasing by 2-3 months of age

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:107927 )

• exocrine tissue of pancreas is inflamed with the acini being replaced by dense sheets of inflammatory cells, necrotic tissue

abnormal pancreas physiology ( J:107927 )

• islets of Langerhans are surrounded by leukocytes and necrotic exocrine tissue

pancreas inflammation ( J:107927 )

• pancreas inflammation is first observed at 1 week of age with the majority of invading cells being macrophages; at 2 months, lymphocytes dominate the inflammation

periinsulitis ( J:107927 )

• in transgenic mice, the islets of Langerhans are surrounded by infiltrates of inflammatory cells: focal accumulations of mononuclear cells are observed at 4-6 weeks of age, increasing by 2-3 months of age

cardiovascular system

abnormal vascular endothelial cell morphology ( J:107927 )

• in transgenic mice at 1 week of age, vessels in the pancreata are larger in diameter than in non-transgenic littermates; in older transgenic mice, the vessels demonstrate areas of inflammation only; endothelial cells lining the small vessels are plump and cuboidal compared to the cells in non-transgenic littermates

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:107927 )

• exocrine tissue of pancreas is inflamed with the acini being replaced by dense sheets of inflammatory cells, necrotic tissue