Phenotypes Associated with This Genotype

Genotype
MGI:3622674

• Allelic Composition: Tg(KRT14-Tslp)1Pcn/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(KRT14-Tslp)1Pcn/0 mice develop a chronic skin inflammation

immune system

enlarged spleen ( J:102470 )

• after week 5, mutants develop splenomegaly

abnormal lymphocyte physiology ( J:102470 )

• at 5 weeks there are increased numbers of lymphocytes and eosinophils in the blood

increased immunoglobulin level ( J:102470 )

• transgenic mice have elevated levels of IgE and IgG in the blood at 5 weeks of age

lymph node hyperplasia ( J:102470 )

• at week 5, mutants display hyperplasia of the lymph nodes

hematopoietic system

enlarged spleen ( J:102470 )

• after week 5, mutants develop splenomegaly

abnormal lymphocyte physiology ( J:102470 )

• at 5 weeks there are increased numbers of lymphocytes and eosinophils in the blood

increased immunoglobulin level ( J:102470 )

• transgenic mice have elevated levels of IgE and IgG in the blood at 5 weeks of age

liver/biliary system

enlarged liver ( J:102470 )

• at week 5, mutants have enlarged livers

hearing/vestibular/ear

scaly ears ( J:102470 )

• at 3 weeks of age, mice display scaly and thickened ears

craniofacial

scaly ears ( J:102470 )

• at 3 weeks of age, mice display scaly and thickened ears

integument

mixed cellular infiltration to dermis ( J:102470 )

• ear skin of transgenics exhibits a dense dermal infiltrate

growth/size/body

scaly ears ( J:102470 )

• at 3 weeks of age, mice display scaly and thickened ears

enlarged liver ( J:102470 )

• at week 5, mutants have enlarged livers

enlarged spleen ( J:102470 )

• after week 5, mutants develop splenomegaly