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Phenotypes Associated with This Genotype
Genotype
MGI:3622479
Allelic
Composition
Braftm1Sva/Braftm1Sva
Tg(Camk2a-cre)1557Sva/0
Genetic
Background
involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Sva mutation (1 available); any Braf mutation (58 available)
Tg(Camk2a-cre)1557Sva mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• six month old mice have poor context discrimination although contextual conditioning is normal
• six month old mice much slower to learn the platform position in a hidden platform Morris water maze (Motor coordination normal)

nervous system
• six month old mice are deficient in the early phase of long term potentiation although there is no disruption of synaptic transmission or presynaptic plasticity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory