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Phenotypes Associated with This Genotype
Genotype
MGI:3622411
Allelic
Composition
Il4tm1Cgn/Il4tm1Cgn
Genetic
Background
NOD.129P2-Il4tm1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Cgn mutation (6 available); any Il4 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl
• amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines
• parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity

endocrine/exocrine glands
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

immune system
• in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls
• at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)

digestive/alimentary system
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:105803


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory