Mouse Genome Informatics
hm
    Il4tm1Cgn/Il4tm1Cgn
NOD.129P2-Il4tm1Cgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl
• amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines
• parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity

endocrine/exocrine glands
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

immune system
• in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls
• at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)

digestive/alimentary system
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:105803