Phenotypes Associated with This Genotype

Genotype
MGI:3622411

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: NOD.129P2-Il4^tm1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:95105 )

• mice are diabetic if 2 consecutive measures of blood glucose are >240 mg/dl

abnormal enzyme/coenzyme activity ( J:105803 )

• amylase activity increases slightly between 4 and 20 weeks of age (234 to 291 U/L) compared to activity in wild-type which declines

• parotid secretory protein protease activity is retained in mutants while non-diseased BALB/c animals do not show activity

endocrine/exocrine glands

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

immune system

decreased susceptibility to autoimmune disorder ( J:95105 )

• in null females challenged with coxsackievirus B4 at 8 weeks of age, diabetes onset is not accelerated as it is in wild-type NOD females; over the 25-week follow up period, only 23% of CVB4 exposed nulls develop diabetes compared to 63% of saline-treated controls

increased susceptibility to autoimmune disorder ( J:95105 )

• at 12 weeks of age, null females challenged with CVB4 develop diabetes at an accelerated rate compared with saline-treated controls (80% at 10 days after infection versus 30% of controls)

digestive/alimentary system

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:105803