Phenotypes Associated with This Genotype

Genotype
MGI:3622353

• Allelic Composition: Foxc2^tm1Miu/Foxc2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymph circulation ( J:83436 )

• 20 of 25 heterozygotes exhibit lymph reflux from the cisterna chyli into dilated lymphatic channels within the hepatic hilum, mesentery, mesenteric lymph nodes and the intestinal wall through incompetent interlymphangion valves

increased lymph node number ( J:83436 )

• 23 of 25 heterozygotes exhibit a general increase in the number of lymph nodes throughout the body

enlarged lymph nodes ( J:83436 )

• 23 of 25 heterozygotes exhibit a general increase in the size of lymph nodes throughout the body

abnormal thoracic duct morphology ( J:83436 )

• 2 of 25 heterozygotes display a hyperplastic thoracic duct with several tortuous bifurcations

lymphangiectasis ( J:83436 )

• heteroygotes show multiple dilated capsular lymphatics and significantly expanded lymph node sinuses (lymphangiectasia), occupying up to 50% of nodal volume

lymphatic vessel hyperplasia ( J:83436 )

• 22 of 25 heterozygotes display a variable but significant increase in the number and caliber of peripheral and central deep lymphatic collectors and trunks and in the superficial dermal lymphatics

vision/eye

abnormal eye morphology ( J:83436 )

• 3 of 25 heterozygotes display ocular dysplasia

abnormal orbit morphology ( J:83436 )

• 3 of 36 heterozygotes exhibit only a vestigial dysplastic ocular remnant unilaterally, associated with a malformation of the orbit

cornea abrasion ( J:83436 )

• 2 of 25 heterozygotes display focal corneal abrasions

cataract ( J:83436 )

• 3 of 25 heterozygotes with cloudy eyes display unilateral cataracts

ocular distichiasis ( J:83436 )

• 100% of heterozygotes (24/24) display an extra internal row of eyelashes arising from the sebaceous meibomian glands

blepharoptosis ( J:83436 )

• 2 of 25 heterozygotes display ptosis of the eye

eye opacity ( J:83436 )

• 5 of 36 heterozygotes exhibit cloudy eyes

homeostasis/metabolism

periorbital edema ( J:83436 )

• 2 of 25 heterozygotes exhibit periorbital swelling

extremity edema ( J:83436 )

• 2 of 25 heterozygotes exhibit hindlimb swelling

lymphedema ( J:83436 )

• 2 of 25 heterozygotes exhibit hindlimb lymphedema; however, no effusions (chylous or non-chylous) or peripheral edema are observed

cardiovascular system

abnormal lymph circulation ( J:83436 )

• 20 of 25 heterozygotes exhibit lymph reflux from the cisterna chyli into dilated lymphatic channels within the hepatic hilum, mesentery, mesenteric lymph nodes and the intestinal wall through incompetent interlymphangion valves

adipose tissue

increased brown adipose tissue amount ( J:83436 )

• heterozygotes exhibit an increased amount of brown fat deposits

craniofacial

abnormal orbit morphology ( J:83436 )

• 3 of 36 heterozygotes exhibit only a vestigial dysplastic ocular remnant unilaterally, associated with a malformation of the orbit

periorbital edema ( J:83436 )

• 2 of 25 heterozygotes exhibit periorbital swelling

skeleton

abnormal orbit morphology ( J:83436 )

• 3 of 36 heterozygotes exhibit only a vestigial dysplastic ocular remnant unilaterally, associated with a malformation of the orbit

growth/size/body

periorbital edema ( J:83436 )

• 2 of 25 heterozygotes exhibit periorbital swelling