Phenotypes Associated with This Genotype

Genotype
MGI:3622335

• Allelic Composition: Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:52940 )

• insulitis begins abruptly between days 15 and 18 after birth; at 14 days after birth, few activated (CD69+) T cells are detected

increased activated T cell number ( J:52940 )

• in transgenic mice, a large proportion of cells in the pancreatic lymph nodes and pancreatic islets have an activated phenotype (CD4+ Vbeta4+) compared to nontransgenic littermates

decreased susceptibility to autoimmune diabetes ( J:87251 )

• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

endocrine/exocrine glands

insulitis ( J:52940 )

• insulitis begins abruptly between days 15 and 18 after birth; at 14 days after birth, few activated (CD69+) T cells are detected

hematopoietic system

increased activated T cell number ( J:52940 )

• in transgenic mice, a large proportion of cells in the pancreatic lymph nodes and pancreatic islets have an activated phenotype (CD4+ Vbeta4+) compared to nontransgenic littermates