Phenotypes Associated with This Genotype

Genotype
MGI:3622272

• Allelic Composition: Lrp4^tm1Her/Lrp4^tm1Her
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:106811 )

• number of homozygotes identified at P5 is much lower than expected, but up to approximately E13, numbers of each genotype is as expected

embryo

thick apical ectodermal ridge ( J:106811 )

• the Fgf8-expressing AER is thickened and broadened in mutants

growth/size/body

abnormal incisor morphology ( J:106811 )

• mutants have mild craniofacial defects usually in the form of incisor defects

abnormal postnatal growth ( J:106811 )

• homozygotes show significantly reduced body weights and postnatal growth compared with wild-type and heterozygotes

limbs/digits/tail

thick apical ectodermal ridge ( J:106811 )

• the Fgf8-expressing AER is thickened and broadened in mutants

abnormal digit morphology ( J:106811 )

• examination 14 day-old mutants revealed fused digital bones and tendons, club-shaped deformities of digital tips and metaphyseal defects

polydactyly ( J:106811 )

• homozygous mice have fully penetrant polysyndactyly of both the fore- and hindlimbs;

abnormal forelimb morphology ( J:106811 )

• extensive bone fusion can be seen in the forelimb

abnormal hindlimb morphology ( J:106811 )

• extensive bone fusion can be seen in the hindlimb

craniofacial

abnormal incisor morphology ( J:106811 )

• mutants have mild craniofacial defects usually in the form of incisor defects

skeleton

abnormal incisor morphology ( J:106811 )

• mutants have mild craniofacial defects usually in the form of incisor defects

abnormal chondrocyte morphology ( J:106811 )

• at E12.5, chondrocye compaction is apparent in the fore- and hindlimbs of mutants; the digital cartilage is broadly fused in mutants as seen at P0