Phenotypes Associated with This Genotype

Genotype
MGI:3622151

• Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs; Adcy8^tm1Ljm/Adcy8^tm1Ljm
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:107678 )

• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished

• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type

increased chemical nociceptive threshold ( J:107678 )

• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts

• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type