Phenotypes for Myl2 Sp4 MGI:3622077 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Myl2^tm1(cre)Krc/Myl2⁺ Sp4^tm2Krc/Sp4^tm2Krc
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (20 available)
Sp4^tm2Krc mutation (0 available); any Sp4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:107057 )

• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40, with it being dispersed throughout the cell instead of localized along the cell boundaries as in wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24