Phenotypes Associated with This Genotype

Genotype
MGI:3622075

• Allelic Composition: Sp4^tm2Krc/Sp4^tm2Krc; Tg(Pax3-cre)1Joe/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal impulse conducting system morphology ( J:107057 )

• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals

• mice have abnormalities in the innervation to the AVN region

abnormal impulse conducting system conduction ( J:107057 )

• atrial paced 2:1 atrioventricular block rates are higher in nulls compared to wild-type

• atrial effective refractory periods are lengthened in null animals

muscle

abnormal impulse conducting system morphology ( J:107057 )

• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals

• mice have abnormalities in the innervation to the AVN region