Phenotypes Associated with This Genotype

Genotype
MGI:3622054

• Allelic Composition: Tnks2^tm1.1Yjc/Tnks2^tm1.1Yjc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:106918 )

N • homozygotes give no indication of embryonic lethality

adipose tissue

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice

growth/size/body

decreased body weight ( J:106918 , J:137985 )

• lower weight in females seen primarily between weeks 5 and 13, weights at 42 weeks not significantly different from controls (J:106918)

• male weights 20% less than controls throughout 42 week observation period (J:106918)

cellular

cellular phenotype ( J:106918 , J:137985 )

N • no alteration in telomere length detected over the course of 7 generations (J:106918)

N • mice exhibit normal cell cycling, irradiation sensitivity and telomere length (J:137985)

decreased adipocyte glucose uptake ( J:137985 )

• adipose glucose uptake is decreased in response to insulin stimulation compared to in wild-type mice