Phenotypes Associated with This Genotype

Genotype
MGI:3621912

• Allelic Composition: Pla2g4a^tm1Tksh/Pla2g4a^tm1Tksh
• Genetic Background: B6.129P2-Pla2g4a^tm1Tksh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:197334 )

N • in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal dye extravasation (a measure of edema) and histamine release from mast cells

abnormal cytokine level ( J:107430 )

• altered levels of Th1 cytokines

decreased interferon-gamma secretion ( J:107430 )

• reduced levels of IFN gamma produced by spleen cells

decreased tumor necrosis factor secretion ( J:107430 )

• reduced levels of TNF produced by spleen cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:107430 )

• mice induced with myelin oligodendrocyte glycoprotein display none of the inflammatory reactions seen in controls

• symptoms are mild and infiltrates primarily restricted to mononuclear cells

homeostasis/metabolism

abnormal cytokine level ( J:107430 )

• altered levels of Th1 cytokines