Phenotypes Associated with This Genotype

Genotype
MGI:3621910

• Allelic Composition: Pla2g4a^tm1Tksh/Pla2g4a^tm1Tksh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:39254 )

N • growth and development normal to 10 months of age

renal/urinary system

abnormal renal tubule morphology ( J:39254 )

• kidneys of 3 out of 5 mice have moderate cytoplasmic vacuolation in the tubular epithelium although there are no indications of abnormal kidney function

reproductive system

parturition failure ( J:39254 )

♀ • females fail to undergo labor at term, offspring born alive do not survive

♀ • if labor is induced using a progesterone receptor antagonist, 3/4 of pups born survive

decreased litter size ( J:39254 )

• homozygous females produce smaller sized litters

• regardless of the paternal genotype

respiratory system

decreased airway resistance ( J:39254 )

• lung resistance induced during anaphylaxis is slightly less than in controls and recovery is much more rapid

• bronchial hyperreactivity induced by anaphylaxis is much reduced, similar to mice unchallenged by antigen

immune system

increased susceptibility to type I hypersensitivity reaction ( J:39254 )

• reduced allergic reaction in experimentally induced anaphylaxis