Mouse Genome Informatics
involves: 129 * C57BL/6J
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after aortic cannulation and Langendorff-perfusion, whole isolated hearts show marked rate slowing
• display ventricular tachycardia during continuous pacing or after the delivery of S2 stimuli at shorter S1-S2 intervals
• exhibit a 50% reduction in sodium conduction, leading to impaired action potential propagation and atrioventricular conduction, delayed intramyocardial conduction, increased ventricular refractoriness, and ventricular tachycardia with characteristics of reentrant excitation
• prolonged PR interval, however QT interval is unchanged
• peak current densities of myocytes are reduced, indicating reduced sodium channel density

Mouse Models of Human Disease
Cardiac Arrhythmia 115000 J:76331
Progressive Familial Heart Block, Type IA; PFHB1A 113900 J:76331