About   Help   FAQ
Phenotypes Associated with This Genotype
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5atm1Agrc mutation (0 available); any Scn5a mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after aortic cannulation and Langendorff-perfusion, whole isolated hearts show marked rate slowing
• display ventricular tachycardia during continuous pacing or after the delivery of S2 stimuli at shorter S1-S2 intervals
• exhibit a 50% reduction in sodium conduction, leading to impaired action potential propagation and atrioventricular conduction, delayed intramyocardial conduction, increased ventricular refractoriness, and ventricular tachycardia with characteristics of reentrant excitation
• prolonged PR interval, however QT interval is unchanged
• peak current densities of myocytes are reduced, indicating reduced sodium channel density

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
progressive familial heart block type IA DOID:0111074 OMIM:113900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory