Phenotypes Associated with This Genotype

Genotype
MGI:3621645

• Allelic Composition: Lcn2^tm1Mak/Lcn2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:106079 )

• accelerated and increased lethality following infection with a lethal dose of E. coli

• a 2.5-fold increase in E. coli numbers is seen after 120 min of incubation with homozygous neutrophils compared to incubation with wild-type neutrophils

• addition of iron to wild-type neutrophil incubations eliminates the difference in bacteria numbers

• however, no difference is seen in overall mortality following injection of 50mg/kg lipopolysaccharide

reproductive system

reduced female fertility ( J:106079 )

♀ • only 68% of females produce their first litter within 8 weeks of mating compared to 95% of wild-type females

renal/urinary system

renal/urinary system phenotype ( J:106079 )

N • kidney development and response to ischemic renal injury are similar to wild-type