Phenotypes Associated with This Genotype

Genotype
MGI:3621642

• Allelic Composition: Erbb2^tm1Klee/Erbb2^tm1Klee; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal myocardial fiber mitochondrial morphology ( J:76196 )

• increase in the numbers of mitochondria

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76196 )

• transthoracic arotic banding results in a significant increase in mortality (70%) versus wild-type (10%)

cardiovascular system

abnormal myocardial fiber morphology ( J:76196 )

• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged

abnormal myocardial fiber mitochondrial morphology ( J:76196 )

• increase in the numbers of mitochondria

abnormal heart ventricle morphology ( J:76196 )

• increase in apoptosis in the ventricles

decreased heart left ventricle septal wall thickness ( J:76196 )

• decrease in LV septal thickness

decreased heart left ventricle posterior wall thickness ( J:76196 )

• decrease in LV posterior wall thickness

dilated cardiomyopathy ( J:76196 )

• mutants display relatively normal function at 6 weeks of age and progressively acquire features of cardiomyopathy over a 6-month period

• exhibit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio

decreased heart ventricle muscle contractility ( J:76196 )

• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure

abnormal cardiac muscle relaxation ( J:76196 )

• reduction in left ventricle dP/dt min indicates impaired left ventricle relaxation

muscle

abnormal myocardial fiber morphology ( J:76196 )

• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged

abnormal myocardial fiber mitochondrial morphology ( J:76196 )

• increase in the numbers of mitochondria

dilated cardiomyopathy ( J:76196 )

• mutants display relatively normal function at 6 weeks of age and progressively acquire features of cardiomyopathy over a 6-month period

• exhibit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio

decreased heart ventricle muscle contractility ( J:76196 )

• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure

abnormal cardiac muscle relaxation ( J:76196 )

• reduction in left ventricle dP/dt min indicates impaired left ventricle relaxation