Phenotypes Associated with This Genotype

Genotype
MGI:3621550

• Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm1Cbm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sympathetic ganglion morphology ( J:48515 )

• lack neural crest cell precursor cells in the anlage of the primary sympathetic ganglion chain

cardiovascular system

abnormal myocardium layer morphology ( J:119151 )

• marker analysis indicates that ventricular myocardial differentiation is impaired

abnormal heart ventricle morphology ( J:119151 )

• marker analysis indicates that ventricular myocardial differentiation is impaired

• however, ventricular cell proliferation is normal

embryo

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

cellular

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

muscle

abnormal myocardium layer morphology ( J:119151 )

• marker analysis indicates that ventricular myocardial differentiation is impaired