Phenotypes Associated with This Genotype

Genotype
MGI:3621490

• Allelic Composition: Dtna^tm1Jrs/Dtna^tm1Jrs; Dtnb^{Gt(OST109050)Lex}/Dtnb^{Gt(OST109050)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:106640 )

• mutants have significantly decreased performance in ability to balance on a small platform, to hang from an inverted screen, or to balance on a rotating rod at constant or accelerating speeds

decreased grip strength ( J:106640 )

• double mutants have significantly poorer performance in a forelimb grip strength test

nervous system

abnormal CNS synapse formation ( J:106640 )

• in double knockouts, inhibitory synapse formation in the cerebellum is defective