Phenotypes Associated with This Genotype

Genotype
MGI:3621352

• Allelic Composition: Cd27^tm1Jbo/Cd27^tm1Jbo
• Genetic Background: either: B6.129P2-CD27^tm1Jbo or 129P2/OlaHsd-Tnfrsf7^tm1Jbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell physiology ( J:65516 )

• thymidine incorporation in T cells exposed to CD3epsilon antibody reduced 1.8x, probably due to reduced survival

• lower response of both CD4+ and CD8+ single positive cells to influenza virus

• reduced memory response

abnormal CD4-positive, alpha-beta T cell physiology ( J:65516 )

• delayed memory response by about 2 days

abnormal cytotoxic T cell physiology ( J:65516 )

• absolute numbers of influenza virus specific CD8+ cells are reduced in the lung

• percentage of influenza virus specific CD8+ cells are reduced in the spleen

• delayed CD8+ memory response

hematopoietic system

abnormal T cell physiology ( J:65516 )

• thymidine incorporation in T cells exposed to CD3epsilon antibody reduced 1.8x, probably due to reduced survival

• lower response of both CD4+ and CD8+ single positive cells to influenza virus

• reduced memory response

abnormal CD4-positive, alpha-beta T cell physiology ( J:65516 )

• delayed memory response by about 2 days

abnormal cytotoxic T cell physiology ( J:65516 )

• absolute numbers of influenza virus specific CD8+ cells are reduced in the lung

• percentage of influenza virus specific CD8+ cells are reduced in the spleen

• delayed CD8+ memory response