Phenotypes Associated with This Genotype

Genotype
MGI:3621152

• Allelic Composition: Ppp1r1b^tm3Pggd/Ppp1r1b^tm3Pggd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:107305 )

• effects of D-amphetamine and LSD on both prepulse inhibition and repetitive movements are attenuated in mutants; effects of PCP on repetitive movements are attenuated

impaired behavioral response to cocaine ( J:106270 )

• mutants self-administer significantly greater numbers of cocaine infusions at 0.5 mg/kg and 0.1 mg/kg doses than do wild-type

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:106270 )

• binge cocaine administration produces increases in extracellular dopamine levels in the dorsal striatum in mutants but the increase is attenuated compared to wild-type