Phenotypes Associated with This Genotype

Genotype
MGI:3621150

• Allelic Composition: Ppp1r1b^tm1Pggd/Ppp1r1b^tm1Pggd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:107305 )

• effects on prepulse inhibition and repetitive movements of each psychomimetic tested are significantly attenuated in mutants compared to wild-type

impaired behavioral response to cocaine ( J:106270 )

• mutant mice take longer (8.8 days) to meet the criteria for cocaine self-administration than wild-type controls (6.2 days)

• mutants administer significantly higher numbers of doses of cocaine at the dose of 0.5 mg/kg per infusion than wild-type controls

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:106270 )

• binge cocaine administration produces increases in extracellular dopamine levels in the dorsal striatum in mutants but the increase is attenuated compared to wild-type