Phenotypes Associated with This Genotype

Genotype
MGI:3620991

• Allelic Composition: Gja1^tm2(Gjb1)Kwi/Gja1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

ventricular premature beat ( J:65112 )

• 2 of 9 exhibit spontaneous singular premature ventricular beats, however ventricular conductance is normal

endocrine/exocrine glands

abnormal milk ejection ( J:65112 )

♀ • heterozygotes exhibit normal mammary gland development and milk production, suggesting that milk ejection is impaired

abnormal mammary gland luminal epithelium morphology ( J:65112 )

♀ • the secretory epithelium is flattened

abnormal mammary gland alveolus morphology ( J:65112 )

♀ • alveoli appear dilated

integument

abnormal milk ejection ( J:65112 )

♀ • heterozygotes exhibit normal mammary gland development and milk production, suggesting that milk ejection is impaired

abnormal mammary gland luminal epithelium morphology ( J:65112 )

♀ • the secretory epithelium is flattened

abnormal mammary gland alveolus morphology ( J:65112 )

♀ • alveoli appear dilated

behavior/neurological

abnormal milk ejection ( J:65112 )

♀ • heterozygotes exhibit normal mammary gland development and milk production, suggesting that milk ejection is impaired

cellular

maternal effect ( J:65112 )

• pups of heterozygous mothers mated to wild-type males, regardless of genotype, gain weight at a severely reduced rate and exhibit high postnatal lethality