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Phenotypes Associated with This Genotype
Genotype
MGI:3620769
Allelic
Composition		 Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (12 available); any Cd80 mutation (42 available)
Cd86tm2Shr mutation (3 available); any Cd86 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:78992 )
• lymph node cells from null animals proliferate poorly compared to wild-type, but do produce IFNG in response to PLP or MOG peptides

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:78992 )
• null mice on the mixed background are resistant to EAE when immunized with either PLP 139-151 or myelin oligodendrocyte glycoprotein 35-55 compared with wild-type (B6 x SJL)F1 mice

nervous system
abnormal spinal cord meninges morphology ( J:78992 )
• numbers of foci in the meninges and parenchyma of the spinal cords of null mice are lower compared to control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory