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Phenotypes Associated with This Genotype
Genotype
MGI:3620768
Allelic
Composition		 Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Genetic
Background		 129.SJL-Cd86tm2Shr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (12 available); any Cd80 mutation (42 available)
Cd86tm2Shr mutation (3 available); any Cd86 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:78992 )
• proliferative responses of lymph node cells to myelin proteolipid protein peptide 139-151 or 178-191 are impaired in null mice compared to wild-type

immune system
decreased interleukin-2 secretion ( J:78992 )
• no IL-2 production could be detected in draining lymph node cells
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:78992 )
• mice develop EAE, but severity is lower and time of onset is delayed compared to wild-type SJL mice
increased susceptibility to experimental autoimmune encephalomyelitis ( J:78992 )
• Background Sensitivity: null mice on a 129 background are susceptible to EAE, whereas nulls on a B6 background are resistant

nervous system
abnormal meninges morphology ( J:78992 )
• in mice exhibiting EAE, there are lesions in the meniges and parenchyma of the spinal cord and brain; number of lesions is lower than in wild-type mice with EAE
• lesions associated with white matter vacuolation occur with higher incidence in null mice compared to wild-type mice with EAE

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory