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Phenotypes Associated with This Genotype
Genotype
MGI:3620632
Allelic
Composition
Hdctm1Nagy/Hdctm1Nagy
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation (0 available); any Hdc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies or altered anxiety in the elevated plus maze or in the open field
• locomotor activation is attenuated after amphetamine administration and mutants become immobile after a high dose of amphetamine
• mutants show increased motor stereotypies compared to controls after amphetamine administration, consisting of repetitive focused sniffing and orofacial movements
• pretreatment with haloperidol, a dopamine D2 receptor antagonist, attenuates the stereotypies induced by amphetamine
• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy
• mutants exhibit less paw-licking behavior (correlated with lowered pain sensitivity) in mutants compared with wild-type in response to subcutaneous injection of capsaicin or formalin
• intrathecal injection of histamine shortened the latency of the tail-flick test in null mice compared to wild-type; i.t. injection of a tachykinin NK1 receptor antagonist significantly inhibited histamine-related nociceptive behaviors in null mice
• the latency to respond to tail pressure is significantly longer in mutants compared to wild-type
• in hot-late, tail-flick and paw-withdrawal tests, the latency to respond to thermal stimuli is significantly prolongedin mutants compared to wild-type

homeostasis/metabolism
• increase in striatal dopamine concentrations during the dark phase
• histamine infusion reduces levels of striatal dopamine

immune system
• mutant mast cells show pale and sparse granules compared to wild-type cells when stained with toluidine blue
• numbers of mast cells in examined mesenterial membrane preparations from mutants are decreased by 55% compared to wild-type; numbers of mast cells in mutants are decreased in peritoneal cell suspensions as well
• tissue histamine levels is almost zero in various organs except for the brain; mast cells in mutants have reduced granular content
• the amount of granular protease in mast cells is decreased in mutants

nervous system
• increase in striatal dopamine concentrations during the dark phase
• histamine infusion reduces levels of striatal dopamine
• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls
• striatal histamine concentrations are reduced
• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum
• mice exhibit a deficit in auditory PPI at three prepulse intensities

hematopoietic system
• mutant mast cells show pale and sparse granules compared to wild-type cells when stained with toluidine blue
• numbers of mast cells in examined mesenterial membrane preparations from mutants are decreased by 55% compared to wild-type; numbers of mast cells in mutants are decreased in peritoneal cell suspensions as well
• tissue histamine levels is almost zero in various organs except for the brain; mast cells in mutants have reduced granular content
• the amount of granular protease in mast cells is decreased in mutants

integument
• mutants exhibit less paw-licking behavior (correlated with lowered pain sensitivity) in mutants compared with wild-type in response to subcutaneous injection of capsaicin or formalin
• intrathecal injection of histamine shortened the latency of the tail-flick test in null mice compared to wild-type; i.t. injection of a tachykinin NK1 receptor antagonist significantly inhibited histamine-related nociceptive behaviors in null mice
• the latency to respond to tail pressure is significantly longer in mutants compared to wild-type
• in hot-late, tail-flick and paw-withdrawal tests, the latency to respond to thermal stimuli is significantly prolongedin mutants compared to wild-type

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Gilles de la Tourette syndrome DOID:11119 OMIM:137580
J:220412


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory